Why More Non-Smokers Are Being Diagnosed with Lung Cancer — And What May Be Behind the Trend

Researchers have found especially high rates of lung cancer linked to pollution in regions such as East Asia and parts of North Africa, where air quality often falls below international health standards. But this isn’t just a problem overseas. Many U.S. cities also struggle with poor air quality, especially during wildfire season or in areas near major highways.

Another invisible threat comes from radon, a naturally occurring radioactive gas that seeps up from the ground. When it becomes trapped inside homes or buildings with poor ventilation, it can silently accumulate to dangerous levels. Prolonged radon exposure has been shown to increase lung cancer risk significantly — even in lifelong non-smokers. The good news is that simple radon testing and improved ventilation can drastically reduce that danger.

The Hidden Influence of Genetics

While environmental risks are easier to measure, genetics can also play a powerful role. Scientists have identified certain gene mutations — including EGFR, ALK, and KRAS — that can trigger tumor growth even in the absence of tobacco exposure. These mutations appear more frequently among non-smokers and may explain why some families seem to face higher lung cancer risks than others.

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