Tricyclic antidepressants, such as amitriptyline, boost the availability of many neurotransmitters while simultaneously having anticholinergic effects. This raises the risk of dementia and cognitive impairment, particularly in older persons.
Statins and cognitive function
Statins, such as simvastatin, lower cholesterol, but long-term use might induce memory issues and mental disorientation. Some studies show an increased risk, while others demonstrate protection against dementia with attenuated results.