Tricyclic antidepressants and memory loss
Tricyclic antidepressants, such as amitriptyline, increase the availability of several neurotransmitters but also have anticholinergic effects. This makes them associated with a higher risk of dementia and cognitive impairment, particularly in older adults.
Today, safer alternatives such as selective serotonin reuptake inhibitors (SSRIs) are available and offer a better safety profile.
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