- Unusual moles that are awry, have uneven borders, or change in color and size (probable signs of melanoma)
- Constantsores that do not heal (may imply skin can.cer)
- Yellowing of the skin and eyes (jaundice) (related to liver or pancreatic can.cer)
- Dark spots or excessive itching (may be related to cancer of internal organs)
4. Persistent pain that doesn’t depart

Chronic pain without an obvious cause can be an early signal of cancer. Cancer-related pain doesn’t improve with rest or medication and may gradually worsen over time.
Possible cancers related to persistent pain:
- Bone can.cer (causing deep bone pain or fractures)
- Brain tumors (causing persistent headaches, nausea, and vision problems)
- Ovarian or colorectal can.cer (causing pelvic or abdominal pain)
- Lung can.cer (causing chest pain and discomfort)
5. Unusual lumps or swelling

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